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 | Acesso ao texto completo restrito à biblioteca da Embrapa Instrumentação. Para informações adicionais entre em contato com cnpdia.biblioteca@embrapa.br. |
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Biblioteca(s): |
Embrapa Instrumentação. |
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Data corrente: |
04/05/2021 |
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Data da última atualização: |
10/06/2022 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
CHAGAS, P. A. M.; SCHNEIDER, R.; SANTOS, D. M. dos; OTUKA, A. J. G.; MENDONÇA, C. R.; CORREA, D. S. |
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Afiliação: |
DANIEL SOUZA CORREA, CNPDIA. |
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Título: |
Bilayered electrospun membranes composed of poly(lactic-acid)/natural rubber: A strategy against curcumin photodegradation for wound dressing application. |
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Ano de publicação: |
2021 |
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Fonte/Imprenta: |
Reactive and Functional Polymers, v. 163, a. 104889, 2021. |
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Páginas: |
1 - 11 |
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ISSN: |
1381-5148 |
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DOI: |
https://doi.org/10.1016/j.reactfunctpolym.2021.104889 |
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Idioma: |
Inglês |
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Conteúdo: |
Curcumin is a natural phenolic compound renowned for its beneficial anti-carcinogenic, anti-oxidant, antibacterial and anti-inflammatory properties. More recently, this active compound has also demonstrated wound healing capability and antibacterial properties, which are essential prerequisites to treat skin injuries. However, the practical application of curcumin in wound-healing dressing is limited by its susceptibility to photodegradation when exposed to artificial or natural sunlight. To maintain the pharmacological and antibacterial properties of curcumin and prevent its photodegradation, we have developed a bilayered asymmetric membrane for wound healing application composed of two layers of electrospun fibers. The bottom layer is composed of a biodegradable blend of poly(lactic acid)(PLA)/natural rubber(NR) microfibers containing curcumin in the bulk. In contrast, the top layer is composed solely of PLA nanofibers to simultaneously protect curcumin against photodegradation and avoid bacterial penetration. Scanning electron microscopy, Fourier transform infrared spectroscopy, UV–Vis spectroscopy, thermal analyses, contact angle measurements and antibacterial assay were employed to investigate the properties of the membranes. Our results demonstrated the top layer of PLA was crucial to prevent the photodegradation of curcumin contained in the PLA/NR microfibers bottom layer and also avoided the penetration of bacteria for 10 days. Additionally, the PLA/NR microfibers showed strong antibacterial activity against Staphylococcus aureus. Our results demonstrated the potential of bilayered nano/microfibrous membranes to be applied in the design of wound dressings containing active compounds susceptible to photodegradation MenosCurcumin is a natural phenolic compound renowned for its beneficial anti-carcinogenic, anti-oxidant, antibacterial and anti-inflammatory properties. More recently, this active compound has also demonstrated wound healing capability and antibacterial properties, which are essential prerequisites to treat skin injuries. However, the practical application of curcumin in wound-healing dressing is limited by its susceptibility to photodegradation when exposed to artificial or natural sunlight. To maintain the pharmacological and antibacterial properties of curcumin and prevent its photodegradation, we have developed a bilayered asymmetric membrane for wound healing application composed of two layers of electrospun fibers. The bottom layer is composed of a biodegradable blend of poly(lactic acid)(PLA)/natural rubber(NR) microfibers containing curcumin in the bulk. In contrast, the top layer is composed solely of PLA nanofibers to simultaneously protect curcumin against photodegradation and avoid bacterial penetration. Scanning electron microscopy, Fourier transform infrared spectroscopy, UV–Vis spectroscopy, thermal analyses, contact angle measurements and antibacterial assay were employed to investigate the properties of the membranes. Our results demonstrated the top layer of PLA was crucial to prevent the photodegradation of curcumin contained in the PLA/NR microfibers bottom layer and also avoided the penetration of bacteria for 10 days. Additionally, the PLA/NR microfibers sh... Mostrar Tudo |
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Palavras-Chave: |
Bilayered membrane; Electrospinning; Polymer nanofibers; Wound dressing. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 02631naa a2200265 a 4500
001 2131659
005 2022-06-10
008 2021 bl uuuu u00u1 u #d
022 $a1381-5148
024 7 $ahttps://doi.org/10.1016/j.reactfunctpolym.2021.104889$2DOI
100 1 $aCHAGAS, P. A. M.
245 $aBilayered electrospun membranes composed of poly(lactic-acid)/natural rubber$bA strategy against curcumin photodegradation for wound dressing application.$h[electronic resource]
260 $c2021
300 $a1 - 11
520 $aCurcumin is a natural phenolic compound renowned for its beneficial anti-carcinogenic, anti-oxidant, antibacterial and anti-inflammatory properties. More recently, this active compound has also demonstrated wound healing capability and antibacterial properties, which are essential prerequisites to treat skin injuries. However, the practical application of curcumin in wound-healing dressing is limited by its susceptibility to photodegradation when exposed to artificial or natural sunlight. To maintain the pharmacological and antibacterial properties of curcumin and prevent its photodegradation, we have developed a bilayered asymmetric membrane for wound healing application composed of two layers of electrospun fibers. The bottom layer is composed of a biodegradable blend of poly(lactic acid)(PLA)/natural rubber(NR) microfibers containing curcumin in the bulk. In contrast, the top layer is composed solely of PLA nanofibers to simultaneously protect curcumin against photodegradation and avoid bacterial penetration. Scanning electron microscopy, Fourier transform infrared spectroscopy, UV–Vis spectroscopy, thermal analyses, contact angle measurements and antibacterial assay were employed to investigate the properties of the membranes. Our results demonstrated the top layer of PLA was crucial to prevent the photodegradation of curcumin contained in the PLA/NR microfibers bottom layer and also avoided the penetration of bacteria for 10 days. Additionally, the PLA/NR microfibers showed strong antibacterial activity against Staphylococcus aureus. Our results demonstrated the potential of bilayered nano/microfibrous membranes to be applied in the design of wound dressings containing active compounds susceptible to photodegradation
653 $aBilayered membrane
653 $aElectrospinning
653 $aPolymer nanofibers
653 $aWound dressing
700 1 $aSCHNEIDER, R.
700 1 $aSANTOS, D. M. dos
700 1 $aOTUKA, A. J. G.
700 1 $aMENDONÇA, C. R.
700 1 $aCORREA, D. S.
773 $tReactive and Functional Polymers$gv. 163, a. 104889, 2021.
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Registro original: |
Embrapa Instrumentação (CNPDIA) |
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Biblioteca(s): |
Embrapa Amazônia Oriental. |
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Data corrente: |
04/07/2018 |
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Data da última atualização: |
22/12/2021 |
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Tipo da produção científica: |
Resumo em Anais de Congresso |
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Autoria: |
LIMA, T. M. R. de; LIMA, K. L. S.; SOUZA, A. M. M.; SOUZA, F. I. B. de; COSTA, P. A. da; XAVIER JUNIOR, S. R. |
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Afiliação: |
Thaina Maria Ribeiro de Lima, UFRA; Keyla Leticia Souza Lima, UFRA; Alisson Matheus Melo Souza, UNAMA; FERNANDA ILKIU BORGES DE SOUZA, CPATU; PALMIRO ALVAO DA COSTA, CPATU; SEBASTIAO RIBEIRO XAVIER JUNIOR, CPATU. |
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Título: |
Lecythidaceae A. Rich. na xiloteca (Embrapa Amazônia Oriental) Belém, Pará, Brasil. |
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Ano de publicação: |
2018 |
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Fonte/Imprenta: |
In: CONGRESSO FLORESTAL LATINO-AMERICANO, 7., 2018, Vitória. [Anais]. [S.l.]: Even3, 2018. |
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Idioma: |
Português |
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Palavras-Chave: |
Acervo; Valor comercial; Xiloteca. |
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Thesagro: |
Lecythidaceae; Madeira. |
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Categoria do assunto: |
K Ciência Florestal e Produtos de Origem Vegetal |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/179409/1/94477.pdf
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Marc: |
LEADER 00690nam a2200217 a 4500
001 2093024
005 2021-12-22
008 2018 bl uuuu u00u1 u #d
100 1 $aLIMA, T. M. R. de
245 $aLecythidaceae A. Rich. na xiloteca (Embrapa Amazônia Oriental) Belém, Pará, Brasil.$h[electronic resource]
260 $aIn: CONGRESSO FLORESTAL LATINO-AMERICANO, 7., 2018, Vitória. [Anais]. [S.l.]: Even3$c2018
650 $aLecythidaceae
650 $aMadeira
653 $aAcervo
653 $aValor comercial
653 $aXiloteca
700 1 $aLIMA, K. L. S.
700 1 $aSOUZA, A. M. M.
700 1 $aSOUZA, F. I. B. de
700 1 $aCOSTA, P. A. da
700 1 $aXAVIER JUNIOR, S. R.
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